Automation of labelling of Lipiodol with high-activity generator-produced Re-188

作者：Lepareur Nicolas^*; Ardisson Valerie; Noiret Nicolas; Boucher Eveline; Raoul Jean Luc; Clement Bruno; Garin Etienne

来源：Applied Radiation and Isotopes, 2011, 69(2): 426-430.

DOI：10.1016/j.apradiso.2010.11.001

• Automation
• High activity
• Lipiodol
• Rhenium-188
• HCC

This work describes optimisation of the kit formulation for labelling of Lipiodol with high-activity generator-produced rhenium-188. Radiochemical purity (RCP) was 92.52 +/- 2.3% and extraction yield was 98.56 +/- 1.2%. The synthesis has been automated with a TADDEO module (Comecer) giving a mean final yield of 52.68 +/- 9.6%, and reducing radiation burden to the radiochemist by 80%. Radiolabelled Lipiodol (Re-188-SSS/Lipiodol) is stable for at least 7 days (RCP=91.07 +/- 0.9%).

• 出版日期2011-2