Nephron-Sparing Surgery for Renal Tumors Measuring More Than 7 cm: Morbidity, and Functional and Oncological Outcomes

作者：Bigot Pierre; Hetet Jean Francois; Bernhard Jean Christophe; Fardoun Tarek; Audenet Francois; Xylinas Evanguelos; Ploussard Guillaume; Pignot Geraldine; Bessede Thomas; Ouzaid Idir; Robine Edouard; Brureau Laurent; de Treigny Olivier Merigot; Maurin Charlotte; Long Jean Alexandre; Rouffilange Jean; Hoarau Nicolas; Lebdai Souhil; Roupret Morgan; Bastien Laurence; Neuzillet Yann; Mongiat Artus Pierre; Verhoest Gregory; Zerbib Marc; Ravery Vincent; Rigaud Jerome

来源：Clinical Genitourinary Cancer, 2014, 12(1): E19-E27.

DOI：10.1016/j.clgc.2013.09.004

• Complications
• Functional outcome
• Nephron sparing surgery
• Oncologic outcome
• Renal cell carcinoma Surgical treatment

Nephron-sparing surgery (NSS) is recommended for renal tumors %26lt; 7 cm and allows better overall survival with oncological results similar to radical nephrectomy. We retrospectively analyzed data from 168 patients treated using NSS for large tumors. In this selected population, patients with elective indication had favorable oncological and morbidity outcomes. NSS indications could be expanded beyond the 7 cm cutoff. %26lt;br%26gt;Background: The purpose of this study was to evaluate morbidity, functional, and oncological outcomes after NSS in renal tumors %26gt; 7 cm. Materials and Methods: We retrospectively analyzed data from 168 patients with tumors %26gt; 7 cm who were treated using NSS between 1998 and 2012. Results: Imperative and elective indications accounted for 76 (45.2%) and 92 (54.8%) patients, respectively. Major perioperative complications and renal function deterioration occurred in 33 (19.6%) and 51 patients (30.4%), respectively. In multivariate analysis, age older than 60 years (P=.001; hazard ratio [HR], 5) and tumor malignancy (P=.014; HR, 6.7) were prognostic factors for renal function deterioration whereas imperative indication was a risk factor for major postoperative complications (P=.0019; HR, 2.7). In 126 (75%) patients with malignant tumors, after a median follow-up of 30 months (range, 1-254 months), 25 patients (20.2%) died. In multivariate analysis, imperative indication (P=.023; HR, 4.2), positive surgical margin (P=.021; HR, 3.3), and Fuhrman grade %26gt; II (P=.013; HR, 3.7) were prognostic indicators for cancer-free survival (CFS). Imperative indication (P=.04; HR, 8.5) and Fuhrman grade %26gt; II (P=.04; HR, 3.9) were predictive factors of cancer-specific survival (CSS). In case of elective indication, positive surgical margin, local recurrence, and cancer-related death occurred in 4 (7.6%), 1 (1.1%), and 1 (1.1%) cases, respectively. For elective indication, 5-year estimates of CFS, CSS, and overall survival rates were: 85.7%, 98%, and 93.9%, respectively. Conclusion: In this selected population, imperative vs. elective indication status seems to play a critical role in oncologic outcomes. Oncologic results for elective indications are close to those reported with radical nephrectomy.

• 出版日期2014-2