Model the evolution of protein interaction network assisted with protein age

作者：Luo, Jiawei^*; Song, Dan; Liang, Cheng; Li, Guanghui

来源：Journal of Theoretical Biology, 2013, 333: 10-17.

DOI：10.1016/j.jtbi.2013.05.006

• Age-dependent duplication-divergence model
• Inverse age-dependent duplication-divergence model

Understanding the dynamic evolutionary process of protein interaction network is fundamental to study cell's activity. As an important attribute of proteins, their age can provide heuristic information for studying the evolution of protein interaction network. In this paper an age-dependent duplication-divergence model (ADD) is proposed to model the evolutionary process of protein interaction network, which integrates the age information of proteins into duplication-divergence (DD) model. Moreover, we also reverse protein interaction network with our model, which is named as inverse age-dependent duplication-divergence model (IADD). The results show that the network built by ADD model conforms to the yeast protein interaction network in the interaction density pattern and other topological properties. The protein age groups predicted by IADD model also show a high agreement with existing research results.

• 出版日期2013-9-21
• 单位湖南大学