Novel Route for the Construction of Chroman Ring System Using Cross-Coupling between Benzylic and Aliphatic Alcohols in the Presence of NaHSO4/SiO2

Aoyama Tadashi<sup>*</sup>; Furukawa Takuya; Hayakawa Mamiko; Takido Toshio; Kodomari Mitsuo

doi:10.1055/s-0034-1380863

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Novel Route for the Construction of Chroman Ring System Using Cross-Coupling between Benzylic and Aliphatic Alcohols in the Presence of NaHSO4/SiO2

作者：Aoyama Tadashi^*; Furukawa Takuya; Hayakawa Mamiko; Takido Toshio; Kodomari Mitsuo

来源：Synlett, 2015, 26(13): 1875-1879.

DOI：10.1055/s-0034-1380863

摘要

Novel route for the construction of chromans from benzylic and aliphatic alcohols in the presence of NaHSO4/SiO2 has been developed. In this reaction, substituted olefins are formed from benzylic and aliphatic alcohols and then converted to chromans through intramolecular cyclization. Twenty novel chromans were synthesized by this simple procedure.