Alcohol consumption and the risk for renal hyperfiltration in the general Chinese population

作者：Lin, M.; Su, Q.; Huang, H.; Zheng, Y.; Wen, J.; Yao, J.; Liang, J.; Li, L.; Lin, W.; Lin, L.; Lu, J.; Bi, Y.; Wang, W.; Ning, G.; Chen, G.^*

来源：European Journal of Clinical Nutrition, 2017, 71(4): 500-505.

DOI：10.1038/ejcn.2016.168

• CHRONIC KIDNEY-DISEASE
• GLOMERULAR HYPERFILTRATION
• FASTING GLUCOSE
• HEAVY DRINKING
• HEART-DISEASE
• METAANALYSIS
• MORTALITY
• HYPERTENSION
• ASSOCIATION
• SMOKING

BACKGROUND/OBJECTIVES: Glomerular hyperfiltration has been considered an early marker of kidney injury in prediabetes and prehypertension. Heavy alcohol consumption remains highly prevalent and is considered a major public health problem worldwide. The degree of glomerular hyperfiltration associated with alcohol consumption remains unclear.
SUBJECTS/METHODS: This study was conducted in three communities in China. A total of 15 390 participants (5396 males and 9994 females) aged 40-65 years were included in the study. Glomerular hyperfiltration was defined as estimated glomerular filtration rate > 97.5th percentile value of the total population.
RESULTS: Current drinkers had a 1.51 times higher risk for developing renal hyperfiltration ( RHF) as compared with never drinkers, adjusted for age, body mass index, smoking status, systolic and diastolic blood pressure, physical activity and the levels of fasting glucose, triglyceride, total cholesterol, low- density lipoprotein and high- density lipoprotein. Furthermore, heavy alcohol consumption of 4210 g per week was associated with an elevated risk for RHF in a dose-dependent manner among male current drinkers.
CONCLUSIONS: In middle-aged Chinese men, heavy alcohol intake was associated with an elevated risk for RHF. On the other hand, former drinkers or light-moderate alcohol intake did not show any increased risks for these conditions.

• 出版日期2017-4
• 单位上海市闵行区中心医院; 福建医科大学; 福建省立医院; 上海交通大学