Associations between regional brain physiology and trait impulsivity, motor inhibition, and impaired control over drinking

作者：Weafer Jessica; Dzemidzic Mario; Eiler William II; Oberlin Brandon G; Wang Yang; Kareken David A^*

来源：Psychiatry Research: Neuroimaging , 2015, 233(2): 81-87.

DOI：10.1016/j.pscychresns.2015.04.010

• Cerebral blood flow
• fMRI
• Inhibitory control
• Stop task
• Alcohol

Trait impulsivity and poor inhibitory control are well established risk factors for alcohol misuse, yet little is known about the associated neurobiological endophenotypes. Here we examined correlations among brain physiology and self reported trait impulsive behavior, impaired control over drinking, and a behavioral measure of response inhibition. A sample of healthy drinkers (n=117) completed a pulsed arterial spin labeling (PASL) scan to quantify resting regional cerebral blood flow (rCBF), as well as measures of self reporLed impulsivity (Eysenck 17 Impulsivity scale) and impaired control over drinking. A subset of subjects (n=40) performed a stop signal task during blood oxygenation level dependeni (BOLD) functional magnetic resonance imaging to assess brain regions involved in response inhibition. Eyscrick 17 scores were inversely related to blood flow in the right precenfral gyrus. Significant BOLD activation during response inhibition occurred in an overlapping right frontal rnoLorfprernoLor region. Moreover, impaired control over drinking was associated with reduced BOLD response in the same region. These findings suggest that impulsive personality and impaired control over drinking are associated with brain physiology in areas implicated in response inhibition. This is consistent with the idea that difficulty controlling behavior is due in part to impairment in motor restraint systems.

• 出版日期2015-8-30