Aptamer-based point-of-care diagnostic platforms

作者：Dhiman Abhijeet; Kaira Priya; Bansal Vipul; Bruno John G; Sharma Tarun Kumar

来源：Sensors and Actuators B: Chemical , 2017, 246: 535-553.

DOI：10.1016/j.snb.2017.02.060

• Aptamers
• Diagnostic
• Point-of-care (POC)
• Aptasensors
• In vitro diagnostics
• Target product profile (TPPs)

This review covers a broad range of well-established and novel diagnostic platforms which are currently being considered for use in commercial point-of care (POC) diagnostics utilizing aptamers instead of antibodies as the molecular recognition elements. Relevant technologies include traditional enzyme-linked colorimetric plate assays, lateral flow test strips, more exotic homogeneous "lights on" fluorescence assays, as well as new nanoparticle-based, electrochemical, electrochemiluminescence and other technologies suitable for rapid and facile POC clinical diagnostics. Advantages of using aptamers over antibodies in such POC diagnostic platforms are elucidated in each case.

• 单位
  河北医科大学