Au Nanowire-on-Film SERRS Sensor for Ultrasensitive Hg2+ Detection

作者：Kang Taejoon; Yoo Seung Min; Yoon Ilsun; Lee Sangyeop; Choo Jaebum; Lee Sang Yup; Kim Bongsoo^*

来源：Chemistry - A European Journal, 2011, 17(7): 2211-2214.

DOI：10.1002/chem.201001663

• DNA
• gold
• mercury
• nanowires
• surface-enhanced Raman scattering

We report an ultrasensitive and selective single nanowire-on-film (SNOF) surface-enhanced resonance Raman scattering (SERRS) sensor for Hg2+ detection based on structure-switching double stranded DNAs (dsDNAs). Binding of Hg2+ induces conformational changes of the dsDNAs and let a Raman reporter get close to the SNOF structure, thereby turning on SERRS signal. The well-defined SNOF structure provides a detection limit of 100 pm with improved accuracy in Hg2+ detection. This sensor is stable over a considerable amount of time and reusable after simple treatment. Since this SNOF sensor is composed of a single Au NW on a film, development of a multiplex sensor would be possible by employing NWs modified by multiple kinds of aptamers.

• 出版日期2011