A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease

作者：Peden John F; Hopewell Jemma C; Saleheen Danish; Chambers John C; Hager Jorg; Soranzo Nicole; Collins Rory; Danesh John; Elliott Paul; Farrall Martin; Stirrups Kathy; Zhang Weihua; Hamsten Anders; Parish Sarah; Lathrop Mark; Watkins Hugh^*; Clarke Robert; Deloukas Panos; Kooner Jaspal S; Goel Anuj; Ongen Halit; Strawbridge Rona J; Heath Simon; Malarstig Anders; Helgadottir Anna; Ohrvik John; Murtaza Muhammed; Potter Simon; Hunt Sarah E; Delepine Marc

来源：Nature Genetics, 2011, 43(4): 339-U89.

DOI：10.1038/ng.782

Genome-wide association studies have identified 11 common variants convincingly associated with coronary artery disease (CAD)(1-7), a modest number considering the apparent heritability of CAD(8). All of these variants have been discovered in European populations. We report a meta-analysis of four large genome-wide association studies of CAD, with similar to 575,000 genotyped SNPs in a discovery dataset comprising 15,420 individuals with CAD (cases) (8,424 Europeans and 6,996 South Asians) and 15,062 controls. There was little evidence for ancestry-specific associations, supporting the use of combined analyses. Replication in an independent sample of 21,408 cases and 19,185 controls identified five loci newly associated with CAD (P < 5 x 10(-8) in the combined discovery and replication analysis): LIPA on 10q23, PDGFD on 11q22, ADAMTS7-MORF4L1 on 15q25, a gene rich locus on 7q22 and KIAA1462 on 10p11. The CAD-associated SNP in the PDGFD locus showed tissue-specific cis expression quantitative trait locus effects. These findings implicate new pathways for CAD susceptibility.

• 出版日期2011-4
• 单位中国地震局