No association between IRF3 polymorphism and susceptibility to hepatitis B virus infection in Chinese patients

作者：Yan, Fang; Gao, Yu-Feng; Lv, Feng; Zhang, Tian-Chen; Li, Xu; Yin, Hua-Fa^*

来源：World Journal of Gastroenterology, 2012, 18(4): 388-392.

DOI：10.3748/wjg.v18.i4.388

• Chronic hepatitis B virus infection
• Interferon regulatory factors tag single nucleotide polymorphisms
• Genetic susceptibility
• Haplotype

AIM: To investigate the association between three tag single nucleotide polymorphisms (tagSNPs) in interferon regulatory factors (IRF3) and the genetic susceptibility to chronic hepatitis B virus (HBV) infection.
METHODS: We performed a case-control study of 985 Chinese cases of chronic HBV infection and 294 self-limiting HBV-infected individuals as controls. Three tagSNPs in IRF3 (rs10415576, rs2304204, rs2304206) were genotyped with the Multiplex SNaPshot technique. The genotype and allele frequencies were calculated and analyzed.
RESULTS: The three SNPs showed no significant genotype/allele associations with chronic HBV infection. Overall allele P values were: rs10415576, P = 0.0908, odds ratio (OR) [95% confidence interval (CI)] = 1.1798 (0.9740-1.4291); rs2304204, P = 0.5959, OR (95% CI) = 1.0597 (0.8552-1.3133); rs2304206, P = 0.8372, OR (95% CI) = 1.0250 (0.8097-1.2976). Overall genotype P values were: rs10415576, P = 0.2106; rs2304204, P = 0.8458; rs2304206, P = 0.8315. There were no statistically significant differences between patients with chronic HBV infection and controls. Haplotypes generated by these three SNPs were also not significantly different between the two groups.
CONCLUSION: The three tagSNPs of IRF3 are not associated with HBV infection in the Han Chinese population.

• 出版日期2012-1-28
• 单位安徽医科大学