Anti-MRSA activity of aldehyde Schiff base N-aryl thiosemicarbazones

作者：Kriushnapriya S^*; Malathy N S; Begum A Shamitha; Baskaran A C; Appalaraju B; Mani K; Kandhaswamy K A

来源：British Journal of Biomedical Science, 2009, 66(1): 14-19.

DOI：10.1080/09674845.2009.11730238

• Antibacterial agents
• Schiff bases
• Staphylococcus aureus
• Thiosemicarbazones
• Methicillin resistance

Eight different newly synthesised aldehyde Schiff base N-aryl thiosemicarbazones, differing in R, R' groups, are tested on 25 clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) and a standard strain. Antibacterial activity was carried out by a well-diffusion method in concentrations of 15-500 mu g/well. Compounds 1, 2,3,4 and 6 showed good inhibition of MRSA. Increasing concentration of the test compounds enlarged the inhibition zone. Determination of minimum inhibitory concentration (MIC) was carried out using a dilution susceptibility test in concentrations of 4-512 mu g/mL of the medium. The lowest MIC value (16 mu g/mL) was produced by compound 4.

• 出版日期2009
• 单位河北医科大学