A novel HLA-B allele, B*5214, detected in a Taiwanese volunteer bone marrow donor using a sequence-based typing method

作者：Chen M J; Chu C C; Shyr M H; Lin C L; Lin P Y; Yang K L^*

来源：International Journal of Immunogenetics, 2010, 37(1): 39-41.

DOI：10.1111/j.1744-313X.2009.00876.x

P>HLA-B*5214, a novel rare allele of HLA-B*52 variant, was found in a Taiwanese volunteer bone marrow donor by sequence-based typing method. The sequence of B*5214 is identical to that of B*520101 in exon 2 but differs from B*520101 in exon 3 at nucleotide positions 419 A -> T and 435 A -> G. Alteration of these two nucleotides resulted an amino acid substitution at amino acid residue 116 Y -> F ( TAC -> TTC) and a silent exchange at residue 121 K -> K (AAA -> AAG).

• 出版日期2010-2