Danhong Inhibits Oxidized Low-Density Lipoprotein-Induced Immune Maturation of Dentritic Cells via a Peroxisome Proliferator Activated Receptor γ-Mediated Pathway

作者：Liu, Hongying; Wang, Shijun; Sun, Aijun; Huang, Dong; Wang, Wei; Zhang, Chunyu; Shi, Dazhuo; Chen, Keji; Zou, Yunzeng; Ge, Junbo^*

来源：Journal of Pharmacological Sciences, 2012, 119(1): 1-9.

DOI：10.1254/jphs.11226FP

• Danhong injection
• dendritic cell
• peroxisome proliferator activated receptor (PPAR) gamma
• atherosclerosis

Danhong injection (DHI), a Chinese Materia Medica standardized product extracted from Radix Salviae miltiorrhizae and Flos Carthami tinctorii, is effective in the treatment of atherosclerosis (AS)-related diseases. It is widely recognized that AS is a complex inflammatory disease of the arterial wall and the dendritic cells (DCs) is a major player in the pathogenesis of AS via mediating atherosclerotic antigen presenting and T lymphocytes. Here, we determined the effect and possible mechanism of DHI on oxidized low-density lipoprotein (ox-LDL)-induced maturation and immune function of DCs. Human monocyte-derived DCs were incubated with DHI or ciglitazone and were subsequently stimulated with ox-LDL to induce maturation. Similar to ciglitazone, a peroxisome proliferator activated receptor (PPAR) gamma agonist, DHI, could significantly reduce ox-LDL-induced expressions of mature markers, enhance the endocytotic function, and inhibit secretions of cytokine on DCs. These effects of DHI could be partly reversed by silencing the PPAR gamma. In conclusion, DHI could inhibit ox-LDL-induced maturation of DCs partly through activating a PPAR gamma-mediated signaling pathway.

• 出版日期2012-5
• 单位中国中医科学院; 复旦大学; 中国中医科学院西苑医院