ANTIBACTERIAL ACTIVITY OF CATIONIC CYCLEN-FUNCTIONALIZED FULLERENE DERIVATIVES: MEMBRANE STRESS

作者：Chen, Q.; Ma, Z.; Liu, G.; Wei, H.; Xie, X.^*

来源：Digest Journal of Nanomaterials and Biostructures, 2016, 11(3): 753-761.

• Fullerene Derivative
• Cyclen Moiety
• Zeta potential
• Bacterial cytotoxicity
• Membrane stress

We report a comparative investigation of the antibacterial activity of the novel water-soluble fullerene derivatives possessing cyclen attached to the cages of C-60 via organic linkers. The posively charged cyclen-functionalized fullerene derivative (CF) showed significant antibacterial activity toword to both Gram negative (E. coli) and positive bacteria (S. aureus). Their antibacterial activities are time and concentration dependent. For cells, the IC50 for E. coli and S. aureus cells are 4.8 mu g/mL and 7.4 mu g/mL, respectively. The bacterial cytotoxicity may be attributed to membrane stress mediated by direct physical contacts. These results suggest that CF might be considered as a novel and promising type of antibacterial drugs.

• 出版日期2016-9
• 单位中国工程物理研究院; 中国工程物理研究院核物理与化学研究所