A Synthetic Adjuvant to Enhance and Expand Immune Responses to Influenza Vaccines

作者：Coler Rhea N^*; Baldwin Susan L; Shaverdian Narek; Bertholet Sylvie; Reed Steven J; Raman Vanitha S; Lu Xiuhua; DeVos Joshua; Hancock Kathy; Katz Jacqueline M; Vedvick Thomas S; Duthie Malcolm S; Clegg Christopher H; Van Hoeven Neal; Reed Steven G

来源：PLos One, 2010, 5(10): e13677.

DOI：10.1371/journal.pone.0013677

Safe, effective adjuvants that enhance vaccine potency, including induction of neutralizing Abs against a broad range of variant strains, is an important strategy for the development of seasonal influenza vaccines which can provide optimal protection, even during seasons when available vaccines are not well matched to circulating viruses. We investigated the safety and ability of Glucopyranosyl Lipid Adjuvant-Stable Emulsion (GLA-SE), a synthetic Toll-like receptor (TLR) 4 agonist formulation, to adjuvant Fluzone(R) in mice and non-human primates. The GLA-SE adjuvanted Fluzone vaccine caused no adverse reactions, increased the induction of T helper type 1 (TH1)-biased cytokines such as IFN gamma, TNF and IL-2, and broadened serological responses against drifted A/H1N1 and A/H3N2 influenza variants. These results suggest that synthetic TLR4 adjuvants can enhance the magnitude and quality of protective immunity induced by influenza vaccines.

• 出版日期2010-10-27