Isolation of 9-Hydroxy-10E,12Z-octadecadienoic Acid, an Inhibitor of Fat Accumulation from Valeriana fauriei

作者：Yuki Keiji; Ikeda Mariko; Miyamoto Kenji^*; Ohno Osamu; Yamada Kaoru; Uemura Daisuke

来源：Bioscience Biotechnology and Biochemistry, 2012, 76(6): 1233-1235.

DOI：10.1271/bbb.110994

• Valeriana fauriei
• 3T3-L1 murine adipocytes
• inhibitor
• fat accumulation

An EtOH extract of Valeriana fauriei was found to exhibit potent inhibition of fat accumulation against 3T3-L1 murine adipocytes. After performing several chromatographic steps, we successfully isolated the conjugated linoleic acid derivative, 9-hydroxy-10E,12Z-octadecadienoic acid (9-HODE). Synthesized 9-HODE and its analogs showed inhibitory activity against fat accumulation.

• 出版日期2012-6