Association of Chlamydia trachomatis Infection With Redetection of Human Papillomavirus After Apparent Clearance

作者：Shew Marcia L; Ermel Aaron C; Weaver Bree A; Tong Yan; Tu Wanzhu; Kester Laura M; Denski Cheryl; Fortenberry J D; Brown Darron R^*

来源：Journal of Infectious Diseases, 2013, 208(9): 1416-1421.

DOI：10.1093/infdis/jit346

• human papillomavirus
• chlamydia
• HPV redetection

Background. Persistent infection with oncogenic human papillomavirus (HPV) is associated with an increased risk of cervical malignancy. Redetection of type-specific HPV after a period of nondetection may be caused by reactivation of a low-level persistent infection. Little is known about factors associated with type-specific HPV redetection.
Methods. For a longitudinal cohort of adolescent women with frequent behavioral and sexually transmitted infection (STI) information (every 3 months), Cox proportional hazard models were used to assess the influence of sexual behaviors and STIs on the redetection of oncogenic or high-risk HPV infections.
Results. A total of 210 type-specific high-risk HPV detection episode periods were identified in this longitudinal cohort; 71 (33.8%) were characterized by a period of nondetection followed by redetection. Chlamydia trachomatis (hazard ratio [HR], 3.14; 95% confidence interval [CI], 1.44-6.86) was associated with redetection; redetection was >2 times more likely with each additional self-reported sex partner in the past 3 months (HR, 2.26; 95% CI, 1.35-3.78).
Conclusions. This study demonstrates the role of C. trachomatis and number of recent sexual partners in type-specific HPV redetection. Given that persistent oncogenic HPV infections are associated with cancer-related outcomes, understanding the potential role of such factors in the pathogenesis of HPV-related outcomes is important.

• 出版日期2013-11-1