The Role of Inflammatory Factors in Pathogenesis of Ischemic Heart Disease

作者：Tatenkulova S N^*; Mareev V Yu; Zykov K A; Belenkov Yu N

来源：Kardiologiya, 2009, 49(1): 4-8.

• coronary heart disease
• heart failure
• cytokines
• endothelial dysfunction
• immune derangements

Purpose. To study mechanisms of immune derangements in coronary heart disease (CH M Material and methods. We measured basic markers of immune activation in 43 patients with CHD and NYHA IAIV class heart failure (HF). There were 41 men and 2 women aged 33 - 64 years (mean 48 +/- 8 years). Concentrations of hsCRP, IgA, IgM, IgG were measured using commercially available kits. IL-8, sIL-2R, IL-6, IL-18, IL-10, IFN-gamma endothelin levels were measured using enzyme-linked immunosorbent assay method. Results. We found evidence of participation of proinflammatory factors in pathogenesis of HF and established associations of mediators of inflammation (CRP, IL-8) with severity of HF, endothelial dysfunction, and impairment of cardiac function.

• 出版日期2009