Anti-Proliferation Effects of Benzimidazole Derivatives on HCT-116 Colon Cancer and MCF-7 Breast Cancer Cell Lines

作者：Al Douh Mohammed Hadi; Sahib Hayder B; Osman Hasnah; Abd Hamid Shafida; Salhimi Salizawati M

来源：Asian Pacific Journal of Cancer Prevention, 2012, 13(8): 4075-4079.

DOI：10.7314/APJCP.2012.13.8.4075

• Benzimidazole
• hydroxyl group
• benzyloxy group
• anti-proliferation
• HCT-116
• MCF-7
• MTT assay

Benzimidazoles 1-4 were obtained using modified synthesis methods and studied for their ability to inhibit cell proliferation of colon cancer cell HCT-116 and breast cancer cell MCF-7 using MTT assays. In the HCT-116 cell line, benzimidazole 2 was found to have an IC50 value of 16.2 +/- 3.85 mu g/mL and benzimidazole 1 a value of 28.5 +/- 2.91 mu g/mL, while that for benzimidazole 4 was 24.08 +/- 0.31 mu g/mL. In the MCF-7 cell line, benzimidazole 4 had an IC50 value of 8.86 +/- 1.10 mu g/mL, benzimidazole 2 a value of 30.29 +/- 6.39 mu g/mL, and benzimidazole 1 a value of 31.2 +/- 4.49 mu g/mL. Benzimidazole 3 exerted no cytotoxity in either of the cell lines, with IC50 values > 50 mu g/mL. The results suggest that benzimidazoles derivatives may have chemotherapeutic potential for treatment of both colon and breast cancers.

• 出版日期2012
• 单位华中科技大学