Zwitterionic Chitosan Derivatives for pH-Sensitive Stealth Coating

作者：Xu Peisheng; Bajaj Gaurav; Shugg Tyler; Van Alstine William G; Yeo Yoon^*

来源：Biomacromolecules, 2010, 11(9): 2352-2358.

DOI：10.1021/bm100481r

Zwitterionic chitosan, a chitosan derivative with a unique pH-dependent charge profile, was employed to create a stealth coating on the cationic surface of drug carriers. Zwitterionic chitosans were synthesized by amidation of chitosan with succinic anhydride. The succinic anhydride-conjugated chitosan had an isoelectric point, which could be easily tuned from pH 4.9 to 7.1 and showed opposite charges below and above the isoelectric point. The succinic anhydride-conjugated chitosan was able to inhibit the protein adsorption to the cationic surface at physiological pH, compatible. with blood components and well tolerated upon intraperitoneal injection. The succinic anhydride-conjugated chitosan has the potential to serve as a coating material to prevent protein adsorption to cationic surfaces, which can be removed in a pH-responsive manner.

• 出版日期2010-9