Age trends in auditory oddball evoked potentials via component scoring and deconvolution

作者：Kerr Cliff C^*; van Albada Sacha J; Rennie Christopher J; Robinson Peter A

来源：Clinical Neurophysiology, 2010, 121(6): 962-976.

DOI：10.1016/j.clinph.2009.11.077

• Auditory oddball
• Evoked potential
• Component scoring
• Deconvolution
• Development
• Aging
• N1
• N2
• P2
• P3

Objective: This study examines developmental and aging trends in auditory evoked potentials (AEPs) by applying two analysis methods to a large database of healthy subjects.
Methods: AEPs and reaction times were recorded from 1498 healthy subjects aged 6-86 years using an auditory oddball paradigm. AEPs were analyzed using a recently published deconvolution method and conventional component scoring. Age trends in the resultant data were determined using smooth median-based fits.
Results: Component latencies generally decreased during development and increased during aging. Deconvolution showed the emergence of a new feature during development, corresponding to improved differentiation between standard and target tones. The latency of this feature provides similar information as the target component latencies, while its amplitude provides a marker of cognitive development.
Conclusions: Age trends in component scores can be related to physiological changes in the brain. However, component scores show a high degree of redundancy, which limits their information content, and are often invalid when applied to young children. Deconvolution provides additional information on development not available through other methods.
Significance: This is the largest study of AEP age trends to date. It provides comprehensive statistics on conventional component scores and shows that deconvolution is a simple and informative alternative.

• 出版日期2010-6