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摘要
The present manuscript involves the synthesis of 5-prop-2-ynylsulfanyl-pyrimidin-4-ones 3a-i by [4+2] cycloaddition reactions of 1,3-diazabuta-1,3-dienes 1a-i with prop-2-ynyl-sulfanyl ketene 2. These 5-prop-2-ynylsulfanyl-pyrimidin-4-ones 3a-i were explored in iodocyclization for the synthesis of novel pyrimido[5,4-b][1,4]thiazines 4a-i in excellent yields. The iodocyclizations followed exo-dig ring-closure cyclizations to yield 6-6 bicyclic fused pyrimidinones, while corresponding endo-dig ring-closure iodoamination was not observed.
- 出版日期2017-5
