Nasal endoscopic evaluation and its impact on survival in patients with stage I/II extranodal natural killer/T-cell lymphoma, nasal type

作者：Cho Hyun Jin; Jang Min Seok; Hong Sang Duk; Kim Seok Jin; Ahn Yong Chan; Oh Dongryul; Ko Young Hyeh; Kim Hyo Yeol; Dhong Hun Jong; Chung Seung Kyu^*; Kim Won Seog

来源：International Forum of Allergy & Rhinology, 2015, 5(10): 960-966.

DOI：10.1002/alr.21564

• extranodal NK-T-cell lymphoma
• lymphoma
• nasal endoscopy
• prognosis
• radiotherapy

BackgroundEndoscopic findings of extranodal natural killer/T-cell lymphoma (ENKTL), nasal type, are heterogeneous, but not fully understood. The objective of this study was to evaluate the role of nasal endoscopic examination and its implications for treatment of stage I/II ENKTL.
MethodsThis retrospective study included 60 consecutive patients diagnosed with stage I/II ENKTL, nasal type, from 2000 to 2011.
ResultsThe endoscopic findings were classified into early (45%) and advanced (55%) lesions. Furthermore, the primary tumor extent assessed by endoscopy was significantly correlated with the radiologic imaging (p < 0.001). The results of univariate analysis showed that the patients with advanced lesions had worse overall survival (p = 0.004) and disease-free survival (p = 0.001) than those with early lesions. In multivariate analysis, advanced lesions on nasal endoscopy was an independent prognostic factor (p = 0.024; hazard ratio 5.29; 95% confidence interval, 1.25-22.39).
ConclusionWe found that nasal endoscopic findings were important prognostic factors in stage I/II ENKTL, nasal type, suggesting that comprehensive endoscopic evaluation of primary tumor should be performed in this setting.

• 出版日期2015-10