Anti-allergic activity of glycyrrhizic acid on IgE-mediated allergic reaction by regulation of allergy-related immune cells

作者：Han, Shiwen; Sun, Lu; He, Feng; Che, Huilian^*

来源：Scientific Reports, 2017, 7(1): 7222.

DOI：10.1038/s41598-017-07833-1

• FC-EPSILON-RI
• URSOLIC ACID
• MICE
• ANAPHYLAXIS
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• EXTRACT
• ASTHMA

Glycyrrhizic acid (GA), the major bioactive triterpene glycoside of glycyrrhiza, has been shown to possess a wide range of pharmacological properties, including anti-inflammatory and anti-viral properties. However, few studies have examined the anti-allergic activity and exact mechanism of action of GA. In the present work, the anti-allergic activity and possible mechanisms of action of GA on an immunoglobulin (Ig) E-mediated allergic reaction has been studied using three models of allergic reaction in vivo and in vitro. Active systemic allergic reaction in Balb/c mice showed that GA can suppress the increased level of IL-4 to restore the immune balance of T(H)1/T(H)2 cells in a dose-dependent manner. Additionally, GA attenuated significantly the B cells producing allergen-specific IgE and IgG(1) partly because of the low levels of T(H)2 cytokines. Both passive cutaneous anaphylaxis in vivo and an RBL-2H3cell-based immunological assay in vitro indicated that GA acted as a "mast cell stabilizer", as it inhibited mast cell degranulation and decreased vascular permeability by inhibiting the expression of Orai1, STIM1 and TRPC1, which blocked extracellular Ca2+ influxes. The current study suggests that GA may serve as an effective anti-allergic agent derived from food for the prevention and treatment of IgE-mediated allergic reaction.

• 出版日期2017-8-3
• 单位中国农业大学