Amyotrophic lateral sclerosis: A neurovascular disease

作者：Garbuzova Davis Svitlana^*; Rodrigues Maria C O; Hernandez Ontiveros Diana G; Louis Michael K; Willing Alison E; Borlongan Cesario V; Sanberg Paul R

来源：Brain Research, 2011, 1398: 113-125.

DOI：10.1016/j.brainres.2011.04.049

• Amyotrophic lateral sclerosis
• Blood-brain barrier (BBB)
• Blood-spinal cord barrier (BSCB)
• Impairment
• Microvascular pathology

Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease with a complicated pathogenesis. Compelling evidence indicates impairment of all neurovascular unit components including the blood-brain and blood-spinal cord barriers (BBB/BSCB) in both patients and animal models, leading to classification of ALS as a neurovascular disease. The present review provides an updated analysis of the normal and impaired BBB/BSCB, focusing on the ALS-altered barrier. Here we describe the roles of cellular components, tight junctions, transport systems, cell interactions, cytokines, matrix metalloproteinases, and free radicals in the BBB/BSCB disruption, along with recent evidence from experimental and clinical ALS studies. The BBB/BSCB is a promising research area in ALS and this review will reveal some aspects of microvascular pathology in ALS and hopefully provide ideas for the development of new therapeutic strategies.

• 出版日期2011-6-29