MicroRNA-613 inhibits the progression of gastric cancer by targeting CDK9

作者：Lu, Yebin; Tang, Ling; Zhang, Qi; Zhang, Zhipeng; Wei, Wei^*

来源：Artificial Cells, Nanomedicine and Biotechnology, 2018, 46(5): 980-984.

DOI：10.1080/21691401.2017.1351983

• miR-613
• CDK9
• gastric cancer
• proliferation
• migration

MicroRNAs (miRNAs) play an important role in the development and progression of human malignancy. miR-613, as a tumour suppressor, was reported to decrease in several tumours. However, the expression levels and role of miR-613 in gastric cancer remain unknown. In this study, we found that miR-613 was evidently downregulated in gastric cancer tissue and cell. The functional analysis showed that miR-613 suppressed cell proliferation and migration in gastric cancer. Next, the dual-luciferase reporter system supported CDK9 as a direct target gene of miR-613. miR-613 mimics evidently repressed CDK9 expression in gastric cancer cells. Furthermore, we found that CDK9 in upregulated in gastric cancer and the CDK9 expression levels were inversely correlated with that of miR-613 in gastric cancer tissues. Overall, the results revealed that miR-613, as a tumour suppressor, involves in gastric cancer progression and metastasis by targeting CDK9, implying a novel potential therapeutic target for the treatment of gastric cancer.

• 出版日期2018
• 单位中南大学