Antibacterial Activities of Iron Chelators against Common Nosocomial Pathogens

作者：Thompson Mitchell G; Corey Brendan W; Si Yuanzheng; Craft David W; Zurawski Daniel V^*

来源：Antimicrobial Agents and Chemotherapy, 2012, 56(10): 5419-5421.

DOI：10.1128/AAC.01197-12

The activities of iron chelators (deferoxamine, deferiprone, Apo6619, and VK28) were evaluated against type strains of Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumoniae, and Escherichia coli. Deferiprone, Apo6619, and VK28 each inhibited growth in standard and RPMI tissue culture medium, while deferoxamine had no effect. Additionally, time-kill assays revealed that VK28 had a bacteriostatic effect against S. aureus. Therefore, these newly developed iron chelators might provide a nontraditional approach for treatment of bacterial infections.

• 出版日期2012-10