Association of T-helper cell cytokine level with age in patients with biliary atresia: a preliminary study

作者：Li, Fu-Bang; Shu, Xiao-Li; Gu, Wei-Zhong; Zhao, Xiao-Xia; Huang, Shou-Jiang; Zhao, Hong; Peng, Ke-Rong; Tou, Jin-Fa^*

来源：World Journal of Pediatrics, 2018, 14(4): 404-409.

DOI：10.1007/s12519-018-0183-1

• Biliary atresia
• Cytokines
• Pathogenesis
• T-helper cell

BackgroundThe pathogenesis of biliary atresia (BA) is associated with an inflammatory process involving the biliary tree. This study aimed to investigate the association of T-helper cell cytokine levels with age in patients with BA.MethodsTwenty-eight patients with BA were divided into three groups according to their age (<2months, 2-3months, and3months). All the patients underwent Kasai portoenterostomy. Blood samples were collected from the patients preoperatively, and the liver tissue specimens were obtained during surgery. We detected serum levels of interleukin (IL)-1, IL-12p70, interferon (IFN)-, IL-6, IL-10, and transforming growth factor (TGF)-1 and liver expression of IL-1, IL-6, and TGF-1.ResultsThe serum levels of IL-1, IL-12p70, IL-6, and IL-10 in patients aged3months were significantly higher than those in patients aged<2months. There were no significant age-related differences in the IL-1, IL-6 and TGF-1 expression levels in the liver tissue of patients with BA.ConclusionsThe serum levels of IL-1, IL-6, IL-10 and IL-12p70 showed significant age-related differences in patients with BA. Interpretation of the role of cytokines in BA needs to take patient's age into consideration.

• 出版日期2018-8
• 单位浙江大学