Mild synthesis of poly(HEMA)-networks as well-defined nanoparticles in supercritical carbon dioxide

作者：Parilti R; Alaimo D; Grignard B; Boury F; Howdle S M; Jerome C^*

来源：Journal of Materials Chemistry B, 2017, 5(29): 5806-5815.

DOI：10.1039/c7tb00740j

Free-radical dispersion polymerisation of 2-hydroxyethyl methacrylate was carried out in supercritical carbon dioxide (scCO(2)) in the presence of stabilisers based on polyethylene oxide (PEO) and poly( heptadecafluorodecyl acrylate) (PFDA). Different architectures of copolymers (random, palm-tree and diblock) were tested for their surface tension, cloud point and as a stabilising agent. The diblock architecture was found to be the best candidate resulting in poly(HEMA) spherical particles with a size of 316 nm. Furthermore, the effect of the CO2-phobic block (PEO) in the diblock architecture was investigated by using three different chain lengths (1000, 2000, 5000 g mol(-1)). By optimizing the stabiliser composition and structure, mild reaction conditions have been identified allowing us to obtain well-defined spherical cross-linked poly(HEMA) particles with a mean diameter of unprecedented low size (216 nm) at a temperature as low as 35 degrees C.

• 出版日期2017-8-7