Nutraceutical potential of polyphenolic fractions from Annurca apple (M. pumila Miller cv Annurca)

作者：Tenore Gian Carlo^*; Campiglia Pietro; Stiuso Paola; Ritieni Alberto; Novellino Ettore

来源：Food Chemistry, 2013, 140(4): 614-622.

DOI：10.1016/j.foodchem.2012.10.112

• Polyphenolic composition
• HepG2 cells
• Glucose uptake
• Cholesterol uptake
• Oxidative stress

The capacities of polyphenolic extracts from Annurca apple peel and flesh to inhibit the glucose and cholesterol uptake by HepG2 cells were evaluated, and compared with those of other conventional cultivars, such as Red Delicious (RD), Pink Lady (PL), Fuji (F) and Golden Delicious (GD). RD peels exhibited the best hypoglycaemic effects, while Annurca flesh appeared the most active in reducing cell cholesterol uptake among the cultivars tested. The influence of the apple polyphenolic extracts on the cell proliferation and oxidative stress was also evaluated. Particularly, RD, Annurca and PL peels decreased proliferation by a 62.5%, 48.0% and 37.5%, respectively, probably due to their prooxidant capacity. Conversely, flesh extracts appeared more protective of cells than peels: Annurca and RD, particularly, proved to be able of increasing proliferation by a 32.2% and 11.1%, respectively, probably due to their capacity of reducing cell physiological radical levels of a 33.3% and 19.9%, respectively.

• 出版日期2013-10-15