N-2-Selective gold-catalyzed alkylation of 1-sulfonyl-1,2,3-trizoles

作者：Ma, Ting; Sun, Chenyang; Yuan, Xiao; Li, Xiaoxiao^*; Zhao, Zhigang^*

来源：RSC Advances, 2017, 7(2): 1062-1066.

DOI：10.1039/c6ra26521a

• NONACTIVATED TERMINAL ALKYNES
• 3-COMPONENT COUPLING REACTION
• CLICK CHEMISTRY
• TRIAZOLE-GOLD
• EFFICIENT SYNTHESIS
• ORGANIC AZIDES
• RECENT TRENDS
• CYCLOADDITION
• 1,2,3-TRIAZOLES
• POLYMERIZATION

An efficient new method was developed to synthesise N-2-alkyl-1,2,3-trizoles via gold catalyzed alkylation of 1-sulfonyl-1,2,3-trizoles with vinyl ethers. Only N-2-isomers were obtained in these reactions. The sulfonyl group in the 1-sulfonyl-1,2,3-trizoles acted as the leaving group, which was trapped by H2O in this reaction.

• 出版日期2017
• 单位西南民族大学