Ameliorative effects of resveratrol on liver injury in streptozotocin-induced diabetic rats

作者：Hamadi Nasereddine; Mansour Ahmed; Hassan Memy H^*; Khalifi Touhami Fatima; Badary Osama

来源：Journal of Biochemical and Molecular Toxicology, 2012, 26(10): 384-392.

DOI：10.1002/jbt.21432

• Diabetes Mellitus
• Oxidative Stress
• Resveratrol
• Streptozotocin

The objective of this study was to investigate the ameliorative property and potential mechanism of resveratrol (RVT) in a dose of 10 mg/kg for 15 consecutive days against liver injury in streptozotocin-induced diabetic rats. Diabetic rats significantly (P %26lt; 0.05) exhibited liver injury manifested by increased aspartylaminotransferase, alanine aminotransferase, and bilirubin; disturbed liver weight to body weight; and confirmed by hematoxylin and eosin staining. Liver from diabetic rats exhibited significant increase in malondialdehyde level and significant decrease in reduced glutathione, glutathione-S-transferase, quinone reductase, catalase, and superoxide dismutase. Diabetic rats showed significant disturbance in serum lipid profile. Treatment with RVT significantly (P %26lt; 0.05) abrogated diabetes-induced perturbation in these parameters and liver histology. These data suggest that RVT treatment is associated with promising hepatoprotective effect against diabetes-induced liver damage via reduction of serum glucose level and oxidative damage and improving serum lipid profile.

• 出版日期2012-10