A meta-analysis of eNOS and ACE gene polymorphisms and risk of pre-eclampsia in women

作者：Shaik A P^*; Sultana A; Bammidi V K; Sampathirao K; Jamil K

来源：Journal of Obstetrics and Gynaecology, 2011, 31(7): 603-607.

DOI：10.3109/01443615.2011.598971

• ACE
• eNOS
• gene polymorphisms
• meta-analyses
• odds ratio
• pre-eclampsia

A meta-analyses of endothelial nitric oxide synthase (eNOS) and angiotensin-converting enzyme (ACE) gene polymorphisms in pre-eclampsia was performed. We shortlisted 33 studies (17 for ACE; 16 for eNOS gene polymorphisms), of which 29 articles (16 for ACE and 15 for eNOS) were analysed. Overall, 1,620 cases with pre-eclampsia and 2,158 controls were analysed for intron 16 insertion-deletion polymorphism in ACE gene. A total of 1,610 subjects with pre-eclampsia and 2,875 controls were analysed for the Glu298Asp in eNOS gene. Overall, the random-effects odds ratio (OR) with Glu298Asp in eNOS gene was 0.958 (95% confidence intervals, CI 0.747-1.228, p > 0.05), and for the insertion-deletion/ACE polymorphism was 0.987 (95% CI 0.698-1.395, p > 0.05). Significant heterogeneity was observed in the studies that evaluated polymorphisms in ACE (Q value == 55.6; I<SU2</SU == 73; p value == 0.000); and eNOS (Q value == 37.2; I<SU2</SU == 62.4; p value == 0.001) polymorphisms. No significant risk of pre-eclampsia was observed in both eNOS and ACE genes with these polymorphisms.</.

• 出版日期2011-10