Antigen-Specific Tolerization and Targeted Delivery as Therapeutic Strategies for Autoimmune Diseases

作者：Shakya, Akhilesh Kumar^*; Nandakumar, Kutty Selva^*

来源：Trends in Biotechnology, 2018, 36(7): 686-699.

DOI：10.1016/j.tibtech.2018.02.008

• Antigen delivery system
• Autoimmune disease
• Autoimmune disorder
• Immune tolerances
• Immunization routes
• Immuno modulations
• Therapeutic effects
• Therapeutic strategy

The prevalence of autoimmune disorders is increasing steadily and there is no permanent cure available. Immunomodulation through repeated exposure of antigens, known as antigen-specific immune tolerance or antigen-specific immunotherapy (ASI), is a promising approach to treat or prevent autoimmune disorders. Different optimization protocols (immunization routes, delivery systems, and approaches) are being developed to implement ASI against self-proteins. Including appropriate adjuvants, altered peptide ligand, and using multipeptides are approaches that can be used to specifically target autoimmunity. This review explores various ASI application methods, including different routes of antigen-specific sensitization, delivery systems, immuno-modulators containing specific antigens, and other targeted approaches that have been successfully demonstrated to have therapeutic effects on autoimmune diseases.

• 出版日期2018-7
• 单位南方医科大学