A novel N,N '-[1,1 '-Dithiobis(phenyl)] bis(salicylaldimine) self-assembled gold electrode for determination of dopamine in the presence of high concentration of ascorbic acid

作者：Behpour Mohsen^*; Ghoreishi Sayed Mehdi; Honarmand Ebrahim; Salavati Niasari Masoud

来源：Journal of Electroanalytical Chemistry, 2011, 653(1-2): 75-80.

DOI：10.1016/j.jelechem.2010.12.027

• Dopamine
• Ascorbic acid
• Self-assembled monolayer
• Electrocatalytic oxidation
• Gold electrode

N,N'-[1,1'-Dithiobis(phenyl)] bis(salicylaldimine) (DTPS) self-assembled monolayer has been fabricated on a bare gold electrode (Au electrode) as a novel sensor for determination of dopamine. The characterization of Au DTPS self-assembled monolayer modified electrode (DTPS SAM-ME) was investigated by cyclic voltammetry and ac impedance spectroscopy using the[Fe(CN)(6)](-3/-4) redox couple. The electroanalytical determination of dopamine was carried out in pH 6.0 0.1 mol L(-1) phosphate buffer solution using differential pulse voltammetry. The diffusion coefficient of dopamine was calculated by chronocoulometry in pH 6.0 phosphate buffer solution to be 6.6 x 10(-5) cm(2) s(-1). A calibration curve was obtained for dopamine in a linear range of 8.0 x 10(-7) to 1.3 x 10(-4) mol L(-1) in the presence of high concentration of ascorbic acid. Selective detection was realized in elimination of ascorbic acid response on the DTPS SAM-ME. The detection limit for dopamine was found to be 3.0 x 10(-8) mol L(-1). The modified electrode showed acceptable selectivity, stability and anti-fouling properties. The results indicated that the DTPS SAM-ME could be employed for the determination of dopamine in pharmaceutical formulations and plasma samples. The lack of a voltammetric response for the oxidation of uric acid demonstrated that the human urine could be used for dopamine recovery tests with adequate selectivity and precision.

• 出版日期2011-4-1