High placenta-specific 1/low prostate-specific antigen expression pattern in high-grade prostate adenocarcinoma

作者：Ghods Roya; Ghahremani Mohammad Hossein^*; Madjd Zahra; Asgari Mojgan; Abolhasani Maryam; Tavasoli Sanaz; Mahmoudi Ahmad Reza; Darzi Maryam; Pasalar Parvin; Jeddi Tehrani Mahmood; Zarnani Amir Hassan

来源：Cancer Immunology, Immunotherapy, 2014, 63(12): 1319-1327.

DOI：10.1007/s00262-014-1594-z

• Immunohistochemistry
• Gleason
• PLAC1
• Prostate cancer
• PSA

The scarcity of effective therapeutic approaches for prostate cancer (PCa) has encouraged steadily growing interest for the identification of novel antigenic targets. Placenta-specific 1 (PLAC1) is a novel cancer-testis antigen with reported ectopic expression in a variety of tumors and cancer cell lines. The purpose of the present study was to investigate for the first time the differential expression of PLAC1 in PCa tissues. %26lt;br%26gt;We investigated the differential expression of PLAC1 in PCa, high-grade prostatic intraepithelial neoplasia (HPIN), benign prostatic hyperplasia (BPH), and nonneoplastic/nonhyperplastic prostate tissues using microarray-based immunohistochemistry (n = 227). The correlation of PLAC1 expression with certain clinicopathological parameters and expression of prostate-specific antigen (PSA), as a prostate epithelial cell differentiation marker, were investigated. %26lt;br%26gt;Placenta-specific 1 (PLAC1) expression was increased in a stepwise manner from BPH to PCa, which expressed highest levels of this molecule, while in a majority of normal tissues, PLAC1 expression was not detected. Moreover, PLAC1 expression was positively associated with Gleason score (p a parts per thousand currency sign 0.001). Interestingly, there was a negative correlation between PLAC1 and PSA expression in patients with PCa and HPIN (p a parts per thousand currency sign 0.01). Increment of PLAC1 expression increased the odds of PCa and HPIN diagnosis (OR 49.45, 95 % CI for OR 16.17-151.25). %26lt;br%26gt;Our findings on differential expression of PLAC1 in PCa plus its positive association with Gleason score and negative correlation with PSA expression highlight the potential usefulness of PLAC1 for targeted PC therapy especially for patients with advanced disease.

• 出版日期2014-12