A novel one-pot synthesis of alpha-keto-1,3,4-oxadiazole derivatives based on isocyanide-Nef reaction

作者：Cui Liren; Liu Qiong; Yu Jingxun; Ni C*******; Yu Hui^*

来源：Tetrahedron Letters, 2011, 52(42): 5530-5533.

DOI：10.1016/j.tetlet.2011.08.086

• 1,3,4,-Oxadiazole
• Isocyanide-Nef reaction
• Dehydrochlorination
• Aza-Wittig condensation

Various alpha-keto-1,3,4-oxadiazole derivatives were synthesized through a sequential intermolecular dehydrochlorination/intramolecular aza-Wittig reaction of carboxylic acids and imidoyl chloride intermediates, which were generated by isocyanide-Nef reaction of acyl chlorides and (N-isocyanimine) triphenylphosphorane (1) in CH(2)Cl(2) at room temperature.

• 出版日期2011-10-19
• 单位同济大学