Novel polystyrene sulfonate-silica microspheres as a carrier of a water soluble inorganic salt (KCl) for its sustained release, via a dual-release mechanism

作者：Sui Cong; Preece Jon A^*; Zhang Zhibing^*

来源：RSC Advances, 2017, 7(1): 478-481.

DOI：10.1039/c6ra25488h

Herein we describe a novel type of organic-inorganic composite solid microsphere, comprised of polystyrene sulfonate and silica (PSS-SiO2), which has been synthesised from polystyrene sulfonic acid and tetraethyl orthosilicate. The microsphere can (i) encapsulate a low molar mass (<100 Da) inorganic salt (KCl), and (ii) provide sustained release (>48 hours) of the salt from the microspheres to an aqueous environment, which has hitherto not been possible. We propose a novel dual-release mechanism of the salt from the microspheres, which leads to the sustained release, and therefore has potential applicability for the controlled and prolonged release of other actives.

• 出版日期2017