The inexpensive additive N-methylmorpholine effectively decreases the equivalents of nucleophiles in the catalytic highly enantioselective arylation of aryl aldehydes

作者：Wang, Pei; Liu, Yue; Zhang, Ya-Lun; Da, Chao-Shan^*

来源：Chirality, 2017, 29(8): 443-450.

DOI：10.1002/chir.22709

• aryl aldehydes
• arylation
• asymmetric catalysis
• NMM
• triarylaluminum

Highly enantioselective arylation of aryl aldehydes catalyzed by (S)-H-8-BINOL-Ti(Oi-Pr)(2) complex in the presence of N-methylmorpholine (NMM) as an effective and inexpensive additive is described for the first time. We found high enantioselectivity and yield but successfully reduced the equivalents of nucleophiles triarylaluminums by 50% compared with our previous report. The practicability of the process was thereby greatly increased.

• 出版日期2017-8
• 单位兰州大学