Acute suppression of TGF-beta with local, sustained release of tranilast against the formation of fibrous capsules around silicone implants

作者：Park Subin; Park Min; Kima Byung Hwi; Lee Ji Eun; Park Hyo Jin; Lee Seung Ho; Park Chun Gwon; Kim Myung Hun; Kim Ryul; Kim Eun Hee; Heo Chan Yeong^*; Choy Young Bin

来源：Journal of Controlled Release, 2015, 200: 125-137.

DOI：10.1016/j.jconrel.2014.12.021

• Capsular contracture
• Fibrosis
• Macrophage
• Silicone implant
• TGF
• Tranilast

We propose the acute, local suppression of transforming growth factor beta (TGF-beta), a major profibrotic cytokine, to reduce fibrosis around silicone implants. To this end, we prepared silicone implants that were able to release tranilast, a TGF-beta inhibitor, in a sustained manner for 5 days or 15 days. We performed histologic and immuno-histochemical analyses for 12weeks after the implantation of the implants in living rats. The capsule thicknesses and collagen densities significantly decreased compared with those around the non-treated silicone implants. Notably, early suppression of TGF-beta affected the fibrogenesis that actually occurs at the late stage of wound healing. This change may be ascribed to the decrease in monocyte recruitment mediated by early TGF-beta during the acute inflammatory reaction. Thus, a significant decrease in differentiated macrophages was observed along with a decrease in the quantity of TGF-beta and fibroblasts during the subsequent inflammation stage; these changes led to a diminished fibrotic capsule formation.

• 出版日期2015-2-28
• 单位河北医科大学