Aminochlorination reaction with N-chlorophthalimide as a new nitrogen/chlorine source resulting in alpha-amino derivatives

作者：Qian Yu; Ji Xiaoyun; Zhou Wei; Han Jianlin^*; Li Guigen; Pan Yi

来源：Tetrahedron, 2012, 68(31): 6198-6203.

DOI：10.1016/j.tet.2012.05.066

• N-Chlorophthalimide
• Aminohalogenation
• beta-Nitrostyrenes
• alpha-Amino compounds

A commercial available compound, N-chlorophthalimide was reported as an efficient nitrogen/chlorine source for the aminohalogenation of beta-nitrostyrenes, which tolerates a wide range of beta-nitrostyrenes substrates with good chemical yields, as well as excellent regioselectivities. The resulted vicinal haloamino nitro products have been converted into several other valuable alpha-amino compounds under simple and mild conditions.

• 出版日期2012-8-5
• 单位南京大学