DPPH-Scavenging Activities and Structure-Activity Relationships of Phenolic Compounds

作者：Zheng, Cheng-Dong; Li, Gang; Li, Hu-Qiang; Xu, Xiao-Jing; Gao, Jin-Ming^*; Zhang, An-Ling

来源：Natural Product Communications, 2010, 5(11): 1759-1765.

• anti-radical
• DPPH
• flavonoids
• phenolic compounds
• structure-activity relationships

Thirty-eight phenolic compounds (including 31 flavonoids) were examined for their DPPH radical-scavenging activities and structure-activity relationships were evaluated Specifically, the presence of an ortho-dihydroxyl structure in phenolics is largely responsible for then excellent anti-radical activity 3-Hydroxyl was also essential to generate a high radical-scavenging activity An increasing number of hydroxyls on flavones with a 3',4'-dihydroxyl basic structure, the presence of a third hydroxyl group at C-5', a phloroglucinol structure, glycosylation and methylation of the hydroxyls, and some other hydroxyls, for example 5-, and 7-hydroxyl in ring A, decreased the radical-scavenging activities of flavonoids and other phenolics

• 出版日期2010-11
• 单位西北农林科技大学