科研之友
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摘要
Introduction: Nuclear factor (NF)-kappa B, as transcription factor, is linked to the expression of various genes and plays an essential role in immune and inflammatory responses. Abnormal NF-kappa B signaling results in human diseases, such as immune disorders, inflammation and various cancers. Therefore, regulation of NF-kappa B may treat or improve the symptoms in human disorders.
Areas covered: This review provides information on recent NF-kappa B inhibitor-related patents from 2006 to 2010. The patents are explained and categorized by mechanism. The reader will gain an understanding of NF-kappa B function and the structure and biological activity of recently developed NF-kappa B inhibitors that may be new drug candidates.
Expert opinion: NF-kappa B plays an essential role in the human body and thus regulation of NF-kappa B is very important for the treatment of diseases. Furthermore, patented compounds and peptides are available as lead compounds in drug development studies.
- 出版日期2011-12
