Association of transient receptor potential canonical type 3 (TRPC3) channel transcripts with proinflammatory cytokines

作者：Thilo Florian; Scholze Alexandra; Liu Dao Yan; Zidek Walter; Tepel Martin^*

来源：Archives of Biochemistry and Biophysics, 2008, 471(1): 57-62.

DOI：10.1016/j.abb.2007.12.006

• transient receptor potential channel
• proinflammatory cytokines
• hypertension

We investigated whether expression of non-selective cation channels of the transient receptor potential canonical (TRPC) channel family are associated with proinflammatory cytokines in monocytes.
Using quantitative RT-PCR we studied the expression of TRPC3, interleukin-1 beta (IL-1 beta), and tumor necrosis factor-alpha (TNF-alpha) in monocytes from 15 patients with essential hypertension and 16 age- and sex-matched normotensive control subjects.
We observed an approximately 8-fold increase of TRPC3 transcripts in monocytes from patients with essential hypertension compared to normotensive control subjects (p < 0.05). We found an approximately 3-fold increase of IL-1 beta, and an approximately 9-fold increase of TNF-alpha in patients with essential hypertension compared to normotensive control subjects (each p < 0.05). We observed a significant correlation between TRPC3 transcripts with systolic blood pressure, expression of IL-1 beta P, and TNF-alpha.
Using quantitative RT-PCR we observed an association of TRPC3 transcripts and proinflammatory cytokines in monocytes.

• 出版日期2008-3-1