Antiproliferative effects of peracetylated naphthoxylosides

作者：Nilsson Ulrika; Jacobsson Marten; Johnsson Richard; Mani Katrin; Ellervik Ulf^*

来源：Bioorganic & Medicinal Chemistry Letters, 2009, 19(6): 1763-1766.

DOI：10.1016/j.bmcl.2009.01.065

• Xylose
• Glycosaminoglycan
• Antiproliferative
• Tumor cells
• Peracetylation

The antiproliferative activity, and the capability of priming of glycosaminoglycan chains, of two series of peracetylated mono- and bis-xylosylated dihydroxynaphthalenes have been investigated for normal HFL-1 cells, as well as transformed T24 cells, and compared to the unprotected analogs. Our data show increased antiproliferative activity upon peracetylation, but a loss of selectivity towards T24 cells.

• 出版日期2009-3-15