Anti-Inflammatory Effects of 4-Methylcyclopentadecanone on Edema Models in Mice

作者：Ma, Yukui; Li, Yue; Li, Xiufeng; Wu, Yingliang^*

来源：International Journal of Molecular Sciences, 2013, 14(12): 23980-23992.

DOI：10.3390/ijms141223980

• 4-methylcyclopentadecanone
• inflammation
• paw edema
• ear edema
• toxicity

The present study evaluated the anti-inflammatory effects of 4-methylcyclopentadecanone (4-MCPC) on edema models in mice and aimed to determine the safety of 4-MCPC after acute exposure. The acute toxicity of 4-MCPC was evaluated by oral administration to rats of single doses of 0, 5, 50, 500 and 5000 mg/kg. Toxic symptoms were observed for 14 days. The anti-inflammatory activity was evaluated in xylene-induced mouse ear edema and carrageenan-induced mouse paw edema. The animals were treated with 4-MCPC once every day for seven consecutive days. Edema index, % inhibition, IL-1, TNF-, PGE(2) and MPO levels in paws were detected after the treatment with xylene or carrageenan. Our results indicated that the LD50 value of 4-MCPC in rats is greater than 5000 mg/kg. The ED50 of 4-MCPC in xylene-induced mouse ear edema model was 7.5 mg/kg. 4-MCPC (8 or 16 mg/kg) remarkably inhibited carrageenan-induced mouse paw edema. Further study revealed that 4-MCPC treatment also decreased IL-1, TNF-, PGE(2) and MPO levels in mice paws. Intragastric administration of 4-MCPC exhibited more significant anti-inflammatory activity than muscone at a dose of 16 mg/kg. Taken together, our results suggest that 4-MCPC has potent anti-inflammatory activity and the mechanisms might be related to the decreases of the levels of IL-1, TNF-, PGE(2) and MPO in inflamed paws.

• 出版日期2013-12
• 单位山东省药学科学院; 沈阳药科大学