摘要

The optimal conditions of the conversion of 16α methyl 3β,17α,21 trihydroxy 5α pregnane 20 one 21 acetate to 16α methyl 11α,17α,21 trihydroxy 1,4 pregndiene 3,20 dione by the mixed cultures of Arthrobacter sp 86 and Metarhizium sp 88 were studied.2%~4%( V/V )N,N dimethylfor...