An Easy Entry into 2-Halo-3-aryl-4(3H)-quinazoliniminium Halides from Heteroenyne-allenes

作者：Naganaboina Vijaya Kumar; Chandra Kusum Lata; Desper John; Rayat Sundeep^*

来源：Organic Letters, 2011, 13(14): 3718-3721.

DOI：10.1021/ol201372n

An efficient three-step synthesis of 2-halo-3-aryl-4(3H)-quinazoliniminium halides from commercially available materials is described. Upon reaction with hydrogen halides, generated in situ from a Lewis acid (MX) and trace water, a variety of easily accessible heteroenyne-allenes underwent facile intramolecular cyclization to afford the title compounds in good yields. The method is highly versatile and provides a general way to construct quinazoliniminium ring systems with a variety of different substitutions.

• 出版日期2011-7-15