A new azo-Schiff base: Synthesis, characterization, biological activity and theoretical studies of its complexes

作者：Al Zoubi Wail; Al Hamdani Abbas Ali Salih; Ahmed Susan Duraid; Ko Young Gun^*

来源：Applied Organometallic Chemistry, 2018, 32(1): e3895.

DOI：10.1002/aoc.3895

• antibacterial activity
• imines
• spectral studies
• theoretical studies
• thermodynamic

A new Azo-Schiff base ligand L was prepared by reaction of m-hydroxy benzoic acid with (Schiff base B) of 3-[2-(1H-indol-3-yl)-ethylimino]-1.5-dimethyl-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylamine. This synthesized ligand was used for complexation with different metal ions like Ni(II), Co(II), Pd(II) and Pt(IV) by using a molar ratio of ligand: metal as 1:1. Resulted compounds were characterized by NMR (H-1 and C-13), UV-vis spectroscopy, TGA, FT-IR, MS, elemental analysis, magnetic moment and molar conductivity studies. The activation thermodynamic parameters, such as E*, H-*, S-*, G(*)and K are calculated from the TGA curves using Coats-Redfern method. Hyper Chem-8 program has been used to predict structural geometries of compounds in gas phase. The biological activities of Schiff base and its complexes had been tested in vitro against, two Gram positive bacteria (Bacillus subtillis and Staphylococcus aureus) and two Gram negative bacteria (Escherichia coli and Pseudomonas aeruguinosa).

• 出版日期2018-1