A Concise and Efficient Synthesis of Substituted Morpholines

作者:Dugar Sundeep; Sharma Amit; Kuila Bilash; Mahajan Dinesh*; Dwivedi Sandeep; Tripathi Vinayak
来源:Synthesis (Germany), 2015, 47(5): 712-720.
DOI:10.1055/s-0034-1379641

摘要

A simple and efficient method has been developed for the synthesis of substituted morpholines by a sequence of coupling, cyclization, and reduction reactions of easily available amino alcohols and -halo acid chlorides. Various mono-, di-, and trisubstituted morpholines, spiro morpholines, and ring-fused morpholines, as well as morpholine homologues, were synthesized in good to excellent yields by a single methodology under similar reaction conditions. The method was also used in a multigram synthesis of (3S)-3-methylmorpholine.

  • 出版日期2015-3